Job Description

Our company's Research Laboratories in South San Francisco is seeking a Senior Scientist with experience in complex cellular model/assay development, mechanistic pharmacology, and lead discovery support to join our Quantitative Biosciences (Pharmacology) department. The successful candidate will be responsible for the design, execution, and interpretation of mid/high throughput cellular assays and mechanistic experimentation to advance early drug discovery projects. The candidate will work closely with a team of multidisciplinary quantitative scientists and other stakeholders to enable strategies for screening, develop assays/models, and execute key mechanism of action studies to advance a diverse portfolio of targeted therapies for oncology (antibody-drug conjugates, T-cell engagers, etc.). We value transparent communication, creative-thinking, teamwork, and rigorous scientific exploration. If you are a highly motivated individual and team player with a strong desire to impact drug discovery, we invite you to consider joining our team.

Key responsibilities:

• Provide cellular pharmacology and assay development expertise to support early drug discovery in oncology with specific focus on targeted therapies

• Develop and execute complex cellular assays for screening and mechanistic characterization of diverse targets and pathways, using a wide range of experimental methodologies

• Implement best experimental practices and leverage lab automation to improve assay operation, quality, and overall productivity

• Identify, evaluate, and champion new enabling technologies and methods

• Ensure high-quality data analysis and timely report generation to project teams

• Properly document experimental designs, findings, and assay protocols, and comply with all laboratory training and safety requirements

• Collaborate with colleagues on multi-disciplinary project teams to provide scientific/technical contributions and deliver on project goals

Qualifications:

Education:

• Bachelor's or Master's in Pharmacology, Cell Biology, or relevant scientific discipline with a minimum ofeight (8) years of drug discovery experience in a biotech/pharmaceutical setting

Required Experience and Skills:

• Highly skilled in the development, execution, and interpretation of mid/high-throughput cellular assays, as well as extensive experience with lead discovery and MoA support

• Strong expertise in the development and optimization of complex oncology and immuno-oncology cellular models, such as those with primary cells, co-culture systems, and 3D spheroids/organoids

• Demonstrated proficiency in a wide range of cell biology techniques (mammalian cell culture, transfection/transduction, CRISPR, etc.) and relevant assay detection technologies (ELISA, AlphaLISA, TR-FRET, BRET, Flow Cytometry, etc.)

• Broad knowledge and hands-on experience with automated liquid handling instruments (Biomek, Bravo, Echo, etc.) and integrated robotic systems for assay operation

• Experience with automated data processing, curve fitting, and visualization software tools

• Rigorous quantitative experimentalist with excellent organization and communication skills and a strong growth mindset

• Demonstrated ability to multi-task and work collaboratively in a cross-functional team environment to execute on project goals and advance drug discovery

Preferred Experience and Skills:

• Prior experience with multiple therapeutic modalities (small molecule, peptide, antibody, antibody drug conjugate, etc.)

• Prior experience as functional area representative in matrixed drug discovery project teams

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected US salary range:

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R319028